Epigenetics of Human Health and Disease - Shelly Berger

Explore the fascinating field of epigenetics and its impact on human health and disease in this comprehensive lecture by Shelly Berger. Delve into key topics such as RNA modifications, histones, and histone modifications, while gaining insights into the role of P53 in cancer development. Learn about wildtype P53 function, its domain structure, and how it acts as an oncogene. Examine hotspot mutations, P53 cells, and the MLL knockdown mechanism. Discover the intricate connections between epigenetics and human cancer, providing a solid foundation for understanding this crucial area of biological research.

Introduction
Epigenetics
RNA Modifications
Histones
Histone modifications
Isomerization
Summary
WildType P53
How does P53 work
P53 as an oncogene
P53 domain structure
Hotspot mutations
P53 cells
MLL knockdown
Mechanism
Human Cancer