Epigenetic Aging Studies in Mammals - Universal DNA Methylation Clocks and Lifespan

Explore a 30-minute webinar on epigenetic aging studies in mammals presented by Dr. Steve Horvath, a renowned expert in aging research, epidemiology, and epigenetics. Delve into the development of universal mammalian epigenetic clocks and their applications in measuring age across species. Learn about the strong association between DNA methylation levels and maximum lifespan in mammals. Discover how these epigenetic clocks can be utilized in various research settings, including in vitro studies, animal models, and human clinical trials. Gain insights into the role of DNA methylation in vertebrate development and disease, the accuracy of epigenetic clocks across different species, and the relationship between age-related conditions and epigenetic age acceleration in various tissues. Examine the effects of sex on epigenetic age acceleration and explore second-generation epigenetic clocks such as DNAM PhenoAge and GrimAge. Understand the implications of these findings for human anti-aging studies and their potential as surrogate endpoints in clinical research.

Intro
Cytosine DNA methylation plays an important role in development and disease of vertebrates
How many probes apply to different phylogenetic orders?
70% of CpG probes map to orthologous genes in humans
Over 10k tissues from 175 species from many phylogenetic orders (red and blue)
Epigenetic clocks for mammals
Highly accurate epigenetic clocks across bat species (Jerry Wilkinson, Joseph Zoller)
Highly accurate epigenetic clocks in pure dog breeds (Elaine Ostrander, Andrew Hogan)
Universal DNA methylation age across mammalian tissues
Central question of biology: Why do similar species, such as mammals, have markedly different maximum lifespans?
Age related conditions versus epigenetic age acceleration in different tissues
Effect of sex on epigenetic age acceleration in different tissues
Second generation epigenetic clocks: DNAM PhenoAge and GrimAge
Meta analysis for the hazard ratio associated with all-cause mortality
Interpreting the hazard ratio from a Cox regression model of GrimAge
Qualifying GrimAge as surrogate endpoint for human anti-aging studies.