Dynamics and Mechanisms of CRISPR-Cas9 Through the Lens of Computational Methods

Explore the dynamics and mechanisms of CRISPR Cas9 through computational methods in this 23-minute webinar presented by Dr. Giulia Palermo, a computational biophysicist and Assistant Professor at the University of California Riverside. Delve into the CRISPR genome-editing revolution and discover how state-of-the-art computations have contributed to understanding this groundbreaking technology. Learn about the refinement of cryo-EM data, enhanced simulations of large-scale conformational transitions, and the mechanism for RNA binding in the formation of a catalytically competent Cas9 enzyme. Gain insights into the biochemistry of CRISPR Cas9 and the mechanism of target effects as Dr. Palermo shares her expertise in this cutting-edge field of life sciences.

Introduction
Mechanism of RNA Binding
Biochemistry of CRISPR Cas9
Mechanism of Target Effects