Cell State Dynamics and Plasticity in Tumorigenesis and Drug Resistance

Explore cell state dynamics and plasticity in tumorigenesis and drug resistance through this comprehensive seminar presented by Dr. Itai Yanai as part of the Mathematical Oncology seminar series. Delve into topics such as cancer cells, heterogeneity, universal modules, and cell state analysis. Examine the principles of natural selection, heritability, and barcoding in the context of cancer research. Investigate the extended phenotype concept and its application to cancer cells' manipulation of fibroblasts. Gain insights into the complexities of cancer biology and potential implications for drug resistance through this in-depth, 1-hour and 28-minute presentation.

Intro
The two stories
Cancer cells
Rules and Principles
Unit of Analysis
Heterogeneity
Universal modules
Color coding
Cell state definition
Cell state analysis
Cell state perturbation
Is it possible
Natural selection
Heritability
Barcoding
Extended phenotype
Snail example
Cancer cells manipulate fibroblasts
The argument doesnt make sense
The punchline