CRISPR 2.0 and the Future of Gene Therapies

Explore the cutting-edge advancements in gene therapy and CRISPR technology in this 27-minute talk by a16z bio deal partner Andy Tran. Delve into the evolution of genetic engineering, from early gene therapy techniques to the current CRISPR 2.0 era and beyond. Gain insights into the revolutionary potential of "living medicines" to precisely target, eliminate, and potentially cure diseases with a single dose. Understand the scientific developments and industry trends driving this paradigm shift in medicine. Learn about the challenges facing the field, including manufacturing and scalability issues, as well as the exciting opportunities for startups in this space. Discover how protein engineering and computational insights are shaping the future of gene therapies. Acquire valuable knowledge on evaluating new companies in this rapidly evolving sector and the potential for niche solutions to address unmet medical needs.

Introduction
How We Got Here
CRISPR 20 Era
The Next Generation
Challenges
Key Areas
Protein Engineering
Computational Insights
Challenges in Manufacturing
Conclusion
Niche Solutions
Evaluating New Companies