Continuous 8 Hz Alternation between Divergent Representations in the Hippocampus

Explore the intricacies of memory-related neural activity in this 33-minute lecture by Loren Frank from UCSF, presented at the Simons Institute. Delve into the expected properties of memory-related activity and the connection between memory and planning. Examine spiking patterns during hippocampal theta sequences and understand co-firing patterns, including normal, anti-synchronous, and synchronous pairs. Investigate alternating representations of future possibilities and their quantification. Learn how theta-timescale activity predicts upcoming choices and analyze the relationship between current and future representations with theta phase. Compare preferred and non-preferred directional representations, and explore the ensemble organization of these representations. Gain insights into theta-paced alteration of directional representations and draw conclusions about the continuous 8 Hz alternation between divergent representations in the hippocampus.

Intro
The Importance of Memory...
Expected Properties of Memory-Related Activity
Memory and Planning
Spiking During Hippocampal Theta Sequences
Expected Co-firing Patterns
Normal, Anti-synchronous and Synchronous Pairs
Alternating Representations of Future Possibilities
Alternating Representations - Quantification
Theta-timescale Activity Predicts Upcoming Choices
Spiking During Theta Sequences
Current vs. Future Representations and Theta Phase
Preferred vs. Non-preferred Directional Representations
Ensemble Organization of Directional Representations
Theta-paced Alteration of Directional Representations
Conclusions