Computational Modelling of Growth and Response of Multicellular EMT6/Ro Spheroids to Multi-Fraction Irradiation

Explore the development of a high-fidelity 'in-silico' multicellular EMT6/Ro spheroidal model in this 55-minute lecture by Monika Joanna Piotrowska from the University of Warsaw. Delve into the evolution of computational cellular automata models for EMT6/Ro spheroid growth, calibrated to various tumor characteristics. Examine the coupled EMT6/Ro tumor growth-multi-irradiation model, which incorporates DNA damage and repair processes, calibrated across 18 independent experimental multi-fraction studies. Learn about the advanced GPU-GA technique developed to conduct highly parallel searches in vast combinatorial spaces, identifying promising irradiation protocol candidates for further clinical study. Gain insights into improving therapeutic outcomes and understanding cancer dynamics under irradiation through this comprehensive computational modeling approach.

[3] S. D. Angus and M. J. Piotrowska. A numerical model of EMT6/Ro spheroid dynamics under irradiation: Calibration and estimation of the underlying irradiation-induced cell survival probability. Journal of Theoretical Biology, 3-32, 2013.