Circadian Rhythms: Past, Present and Future - Michael Rosbash

Explore the fascinating world of circadian rhythms in this comprehensive lecture by Michael Rosbash. Delve into the history, current understanding, and future implications of these biological timekeepers. Learn about light entrainment, light-dark cycles, and their impact on various organisms from cyanobacteria to animals and plants. Discover the evolutionary aspects of circadian rhythms and the genetic foundations that led to groundbreaking research. Understand the molecular mechanisms behind the feedback loop and temporal profiles that govern these rhythms. Examine the challenges in the field, including the range of entrainment and its physiological effects. Investigate the connections between circadian rhythms and metabolism, diabetes, and sleep disorders. Gain insights into time-restricted feeding and sleep phase syndromes, and their potential implications for human health and well-being.

Intro
Light entrainment
Lightdark cycle
Cyanobacteria
Animals and Plants
Evolution
The assay
The first paper
Why genetics
Feedback loop
Molecular picture
Temporal profile
Challenges
Range of Entrainment
Circadian Rhythms and Physiology
Metabolism and Diabetes
Time Restricted Feeding
Sleep Disorders
Sleep Phase Syndromes