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Spectral Decomposition of Atomic Structures in Heterogeneous Cryo-EM

Offered By: Institute for Pure & Applied Mathematics (IPAM) via YouTube

Tags

Cryo-Electron Microscopy Courses Structural Biology Courses Atomic Structure Courses Spectral Decomposition Courses

Course Description

Overview

Explore a cutting-edge approach to recovering three-dimensional atomic structures of flexible macromolecules from heterogeneous single-particle cryo-electron microscopy (cryo-EM) datasets in this 51-minute conference talk. Delve into the innovative method that combines prior biological knowledge with cryo-EM images to determine atomic structure deformations. Learn how the space of possible atomic structures is parametrized using biological knowledge, and how conformation parameters are estimated through a linear combination of leading eigenvectors from a graph Laplacian. Discover how this technique approximates the spectral properties of the macromolecule's conformation manifold, offering new insights into structural biology and cryo-EM analysis.

Syllabus

Carlos Esteve Yague - Spectral decomposition of atomic structures in heterogeneous cryo-EM


Taught by

Institute for Pure & Applied Mathematics (IPAM)

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