Breast Cancer Risk Assessment Using the Tyrer Cuzick Model - Webinar - Ambry Genetics

Explore breast cancer risk assessment using the Tyrer-Cuzick model in this informative webinar presented by Dr. Jack Cuzick, a renowned epidemiologist and cancer prevention expert. Gain insights into major breast cancer risk factors and learn how they are combined to create risk estimates for women without breast cancer. Discover recent additions to the model, including mammographic breast density and polygenic risk scores based on common single nucleotide polymorphisms. Examine analyses from large cohorts demonstrating the model's application, and understand its potential uses in risk-adapted screening strategies and preventive therapy selection. The presentation covers various aspects of risk assessment, including family history, reproductive factors, hormones, benign breast disease, and mammographic density, providing a comprehensive overview of this important tool in breast cancer prevention and early detection.

Intro
Who is Dr Kuzak
Disclosure
Gail Model
Boadicea Model
IBIS Model
IBIS Version 8
Family History
First Degree Relatives
Reproductive Factors
Family Size Breastfeeding
Other Reproductive Factors
Other Hormones
Benign Breast Disease
Mammography Density
Breast Density
Tyrer Cuzick Model
Average Risk
Probability
The Model
The Family History
Relative Hazards
Density
Percent Density
Gareth Evans
Risk Assessment Questionnaire
Cohort
Results
Volumetric Data
By Rats
Risk Curves
Summary
Risk without density
Risk with density
Polygenic risk scores
Polygenic risk profiles
Procast cohort
More data
Future
Questions
Oral contraceptives
Oral contraceptives vs hormone replacement
Hormone replacement therapy
Risk due to benign disease
Risk due to lumpectomy
Risk due to another gene mutation
Gene testing
Next version
Two more questions
Is there more than masking
Thank you
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