Using Resting State fMRI to Look at Everything but Neuronal Activation

Explore a 42-minute lecture on using resting state fMRI to examine non-neuronal activation aspects of brain function. Delve into the intricate relationship between blood flow and brain activity, analyzing various frequency bands and low-frequency oscillations. Investigate the connection between BOLD signals and NIRS, and examine global hemodynamic fluctuations. Learn about innovative testing methods, including activation at progressive time delays and systematic evaluation techniques. Discover how these signals permeate areas with blood flow and utilize dual regression for correlation analysis. Gain insights into methodological improvements, including studies on squirrel monkeys and Voss' hypersampling method with Analytic Phase Projection. Examine hypersampled cardiac waveforms from the Human Connectome Project and explore beat-to-beat heart rate details, providing a comprehensive understanding of non-neuronal factors in resting state fMRI.

Intro
Blood and the Brain
Frequency bands
Low frequency oscillations
BOLD and NIRS
Is it global hemodynamic fluctuations?
How do we test this?
Activation at Progressive Time Delays
Systematic evaluation
These signals go everywhere blood goes
Use dual regression to look for correlations
If the moving component is noise...
Methodological improvements
Average data from 12 squirrel monkeys
Voss' method - Hypersampling with Analytic Phase Projection
Hypersampled cardiac waveform (HCP)
Observation
HCP example
Hypersampled cardiac waveform (myconnectome)
Beat to beat heart rate detail