Cerebellar Orchestration of Motor Behavior and Cognition

Explore the intricate workings of the cerebellum in this 56-minute BrainMap seminar presented by Chris De Zeeuw, PhD, from Erasmus MC and Netherlands Institute for Neuroscience. Delve into the cerebellar orchestration of motor behavior and cognition, examining key concepts such as vestibulo-ocular reflex learning, Pavlovian eyeblink conditioning, and cognitive learning. Investigate the roles of Upbound and Downbound modules, long-term potentiation plasticity, and the functional significance of MDJ input. Gain insights into how different cerebellar modules operate in synergy to control complex behaviors, using examples like the "Ronaldo experiment" to illustrate these principles. Enhance your understanding of cerebellar function and its impact on motor skills and cognitive processes through this comprehensive exploration of cutting-edge neuroscience research.

Intro
How does our cerebellum orchestrate our behaviour?
Learning of vestibulo-ocular reflex in Upbound module
SS firing frequency increases during Upbound learning
Long-term potentiation plasticity dominates Upbound learning
Hypothesis 2: Potentiation during Upbound learning depends on CS decrease
Downstream polarity of Upbound modules is negative
Pavlovian eyeblink conditioning in Downbound module
Hypothesis 1: SS firing frequency decreases during Downbound leaming
Downstream polarity of Downbound modules is positive
The Ronaldo experiment
Cognitive Learning: Different modules operate in synergy
What is the functional role of the MDJ input?
Cognitive Learning depends on MDJ input
Downbound modules are more sensitive