An Aid to Antibiotic Decision Making

Explore the complexities of antibiotic decision-making in this 46-minute physician grand rounds presentation by Dr. Trevor Van Schooneveld from the University of Nebraska Medical Center. Delve into the challenges of diagnosing bacterial infections, understand the importance of biomarkers like procalcitonin (PCT), and learn about their dynamics in clinical settings. Examine case studies, multicenter randomized controlled trials, and sepsis algorithms to gain insights into PCT-guided treatments. Discover when PCT is most effective and how to implement it in clinical practice. Enhance your knowledge of antibiotic stewardship and improve patient care through evidence-based approaches to infectious disease management.

Intro
Objectives
Case 1
Diagnosis of Bacterial Infection is Difficult
Biomarkers of Bacterial Infection
PCT Dynamics Are Important
Procalcitonin Dynamics Summary
Keep In Mind the Confounders
Clinical Application
Conclusions: Respiratory Tract Infection
The Sepsis Dilemma
PRORATA - Multicenter RCT PCT-Guided Sepsis Treatment
SAPS Study Stop Antibiotics on Procalcitonin Guidance Study
Sepsis algorithm: Initial PCT
Sepsis algorithm: Follow up PCT
When is PCT less useful?
PCT Implementation
Key Points
Case 2
Questions?