Aminoglycosides - Clinical Uses and Adverse Effects

Explore the clinical uses and adverse effects of aminoglycosides in this comprehensive 32-minute video lecture. Learn about the major toxicities, including ototoxicity, nephrotoxicity, and paralysis, as well as precautions for pregnant women. Discover the advantages of topical administration and high-dose extended interval regimens. Understand the synergistic use of aminoglycosides and their applications in various infections, such as neonatal meningitis, sepsis, pulmonary infections, cystic fibrosis, and infective endocarditis. Examine the use of aminoglycosides in infections above and below the diaphragm, including bone and joint conditions and skin and soft tissue infections. Gain insights into the specific use of neomycin in hepatic encephalopathy and learn when aminoglycosides are used as monotherapy.

Aminoglycosides are Toxic drugs to be used cautiously
Major toxicities of Aminoglycoside
Adverse affect :Ototoxicity
Adverse affect :Nephrotoxicity
Adverse affect :Paralysis
Avoid in Pregnant women
Topical administration is safer
High dose extended interval regimen
Adverse affect of Nephrotoxicity is reversible while ototoxicity is irreversible
synergictic use of Aminoglycosides and its advantages
Clinical uses of Aminoglycosides
Aminoglycoside use in neonatal meningitis and sepsis.
Aminoglycoside use in pulmonary infections including pneumonia and abscess
Difference between nectrotizing pneumonia and pulmonary abscess .
Cystic fibrosis infections involve pseudomanas aeroginosa organism
Aminoglycoside use in infective endocarditis
List of infections above the diaphragm for which Aminoglycosides are used.
- Use of Aminoglycosides for prophylaxis and infections below diaphragm.
Neomycin use in hepatic encephalopathy
Review of clinical uses of aminoglycoside.
Use in Bone and joint conditions
Use in skin and soft tissue infections
Aminoglycoside only used as monotherapy