A Multiscale Model of the CD8 T-Cells Immune Response

Explore a 30-minute lecture on the mathematical modeling of CD8 T-cell immune responses presented by Simon Girel from Université Côte d'Azur at Institut Henri Poincaré. Delve into two distinct models: an impulsive differential equation examining the impact of unequal molecular partitioning during cell division on molecular heterogeneity regulation, and an agent-based model integrating discrete CD8 T-cell populations with their molecular content. Discover how these models reproduce key phases of the CD8 T-cell response at both cellular and molecular levels, supporting the hypothesis that in vivo cell dynamics result from molecular heterogeneity within the CD8 T-cell population. Gain insights into the complex proliferation and differentiation program of CD8 T-cells triggered by pathogen infection and controlled by evolving molecular content.

A multiscale model of the CD8 T-cells immune response