Cross-Species Translation Through Computational Analyses - Implications for Understanding and Modifying Psychiatric Treatments

Explore the implications of computational psychiatry in this 55-minute lecture by A. David Redish from the University of Minnesota, Twin Cities. Delve into how psychiatric dysfunctions can be viewed as information processing problems and the three key implications of this framework. Learn about aligning diagnosis with computational failure modes, modifying information processing for treatment, and ensuring computational parallels for cross-species translation. Examine concrete examples that illustrate these concepts, including serial reaction time tasks, map-based logic, and anticipatory behaviors. Gain insights into procedural systems, ballistic movements, and animal vs. human thresholds. Discover how this approach can lead to new understandings of psychiatric treatments and improved animal models for research.

Introduction
Ethology
Two starting points
Two examples
Serial reaction time task
Mapbased logic
Leftright alternate task
Example
Anticipatory behaviors
Procedural system
Ballistic movement
Restaurant Row
Animal Thresholds
Human Thresholds
Sinking Costs
Implications for psychiatry
Failure modes
Contingency management
Three thoughts