Preparing Single Enantiomers and Conformational Energy - Freshman Organic Chemistry

Explore the intricacies of preparing single enantiomers and understanding conformational energy in this 49-minute lecture from Yale University's Freshman Organic Chemistry course. Begin with an examination of the legal implications of chirality before delving into three general methods for producing single enantiomers, using esomeprazole as a practical example. Investigate the subtle nature of conformational isomerism, focusing on rotations about single bonds and their energetic considerations. Learn about conformational notation and nomenclature, including Newman projections. Discover how the barrier to rotation about the C-C bond in ethane was determined through heat capacity measurements. This comprehensive lecture covers essential topics in organic chemistry, providing a solid foundation for understanding molecular structure and behavior.

- Chapter 1. Introduction: Legal Implications of Chirality.
- Chapter 2. Methods for Isolating Esomeprazole into a Single Enantiomer.
- Chapter 3. Conformational Isomerism: An Introduction.
- Chapter 4. Newman Projections and Nomenclature for Conformations.
- Chapter 5. Understanding the Barrier to Rotate about the C-C Bond of Ethane.