Updated Lymphoma Classification in WHO 5th Edition - Lecture 21

Explore the latest updates in lymphoma classification with Dr Eman Aljufairi's 40-minute lecture from The Royal College of Pathologists. Delve into the evolution of lymphoma classification, from morphology-based approaches to the integrated system incorporating clinical features, behavior, morphology, immuno-phenotype, and molecular alterations. Learn about the key changes introduced in the 5th edition of WHO classification of hematolymphoid tumours (2022), including modifications to follicular lymphoma classification, redefinition of large B-cell lymphoma subtypes, and molecular updates in peripheral T-cell lymphomas. Cover topics such as lymphoplasmacytic lymphoma, follicular lymphoma variants, double-hit lymphomas, high-grade B-cell lymphomas with specific genetic aberrations, primary large B-cell lymphoma of immune-privileged sites, ALK-negative large cell lymphoma, and peripheral T-cell lymphoma, NOS. Gain valuable insights into the current state of lymphoma classification and its implications for diagnosis and treatment.

Intro
A Bit of History....
Lymphoplasmacytic Lymphoma
Follicular Lymphoma
Classic FL
FL with unusual cytological feature
Follicular large B-cell lymphoma
Double-Hit Lymphoma
DLBCL/HGBL with MYC and BCL2 rearrangements
High grade B-cell lymphoma with 11c aberration
Primary large B-cell lymphoma of imr privileged sites
Alk-Negative Large Cell Lymphom
Peripheral T-cell Lymphoma, NOS