Bone Marrow Transplant in Sickle Cell Disease

Explore the indications, techniques, and complications of bone marrow transplantation in sickle cell disease in this 45-minute lecture. Delve into the pathophysiology, donor selection process, and various stem cell sources. Learn about conditioning agents, pre-transplant discussions, and the ideal regimen for BMT in SCD. Examine common complications such as graft-versus-host disease, posterior reversible encephalopathy syndrome, sinusoidal obstruction syndrome, and transplant-associated microangiopathy. Gain insights into the challenges faced during BMT for sickle cell patients and understand the current treatment approaches.

Intro
Objectives
Pathophysiology
Bone Marrow Transplantation in Sickle Disease
Other Stem Cell Sources
Principles of Bone Marrow Transplant
Common Conditioning Agents used in BMT
Discussions prior to BMT in SCD
Donor Selection
Complications of Bone Marrow Transplar
Challenges of BMT in Sickle Cell Disease
Ideal Regimen for BMT SCD
Indications for BMT in Sickle Cell Disease
Graft versus Host Disease
Treatment
Posterior Reversible Encephalopathy Syn
PRES - management
Sinusoidal Obstruction Syndrome
Transplant Associated Microangiopathy