Stereochemistry

Stereochemistry of molecules dictates isomerism, chemical and biochemical reactivity. Reactivity. These days, chiral drugs have become an integral part of pharmaceutical industry. A basic concept on 3D structures and conformations of molecules and asymmetric synthesis and other stereochemical principles and attributes are essential. This course will lay the foundation on to which further advanced topics can be built up.INTENDED AUDIENCE :Chemistry, Biotechnology, Bioscience and Pharmacy.PRE-REQUISITES : +12 ChemistryINDUSTRY SUPPORT : Pharmaceutical industries, Perfumery Industries

Week 1: Constitution and Configuration; Chemistry in 3D space Chirality and its origin, symmetry criterion;Week 2: Stereogenicity and topicity; Enantiomers, Diastereomers, Epimers, Anomers, AtropisomersWeek 3: Nomenclature: Absolute (R/S and D,L) and relative configurations (Threo/erythro , syn/anti and like/unlike)Week 4: Prochirality, pro-R and pro-S designations; related problemsWeek 5: Conformations of acyclic systems: X-CH2-CH2-X and of cyclic systems: cyclopropane, cyclobutane, cyclopentaneWeek 6: Conformations of cyclohexane (including mono and disubstituted), cis and trans-decalinsWeek 7: Stereoelectronic and steric principles in reactions: Substitution, elimination and addition; selectivity and specificityWeek 8: Stereoelectronic and steric principles in reactions: Substitution, elimination and addition; selectivity and specificity (contd);Importance of stereochemistry in real life: some examples