Organ Printing

ABOUT THE COURSE:Printing of tissue analogs recapitulating the structure and function of native tissues are beneficial for many applications like tissue engineering, in vitro tissue modeling, cancer modeling, and for studying tissue/organ development process. Organ printing or 3D bioprinting uses a layer-by-layer manufacturing process with all the components of a tissue like cells, matrix materials and bioactive factors to produce artificial tissues. Various aspects of this technology will be described in this course starting from the fundamental of 3D Bioprinting, process parameters, bioinks used to organ-specific strategies for tissue printing. Moreover, the applications of this technology will be described with examples from recent literatures and reports.PRE-REQUISITE:Knowledge on Biomaterials and Human Anatomy and Physiology.INTENDED AUDIENCE:Students from Bioengineering/Biomedical Engineering/Biotechnology programs.INDUSRTY SUPPORT:Relevant Industries of Biotechnology/Biomaterials/Tissue Engineering.

Week 1: Introduction to Bioprinting; different types of bioprinting techniques and their advantages and disadvantages Week 2: 3D tissue designing and 3D tissue/organ printing; various process parameters and their role in bioprinting Week 3: Introduction to bioinks; biomaterials used for bioink development with their merits and demerits Week 4: Critical parameters of bioink formulations for bioprinting, modulation of bioink properties to control different processing conditions Week 5: 3D bioprinted in vitro, in vivo, and ex vivo research models and techniques; in vitro manipulation of cells and biomaterials with a bioprinter to engineer tissues for regenerative medicine or in vitro tissue/organ models Week 6: In situ bioprinting and 4D bioprinting with examples from recent literature Week 7: Biofabrication-based strategies from bench-to-bed to address specific clinical problems Week 8:Next step in bioprinting (challenges and future direction); ethical issues related to bioprinting