One and Two dimensional NMR Spectroscopy: Concepts and Spectral Analysis

ABOUT THE COURSE: The present course is incisive and I give deeper concepts. In addition to fundamental concepts of 1D and 2D NMR, a large number of examples of spectral analysis will be given. I also plan to cover the NMR of several nuclei, 19F, 29Si, 77Se, 199Hg, 6Li, etc. The 1D Steady State NOE, 2D Transient NOE, and number of 2D sequences will be discussed. The course is aimed to provide deeper insights into concepts of NMR and would make the participants comfortable with umpteen examples.INTENDED AUDIENCE: PG Students, Research Scholars in Chemistry, Physics, Pharmacy.PREREQUISITES: No prior requirement as I cover from basics and take the participants with me. However, MSc in Physics, Chemistry and Pharmacy is preferred.INDUSTRY SUPPORT: All the Pharma Industry R and D people could be benefitted from this course.

Week 1:NMR Spectroscopy, Spin physics, Fundamental conceptsWeek 2:NMR Interaction Parameters, Chemical Shifts Week 3:NMR Interaction Parameters, Scalar Couplings, Multiplicity patterns, Spectra of Strong and Weakly Coupled spinsWeek 4:Analysis of 1D 1H NMR Spectra, with numerous examplesWeek 5:Spin Echoes, APT, INEPT, and DEPTWeek 6:Basics of NOE, Steady state NOE, and applicationsWeek 7:13C NMR, Various decoupling modes, Interpretation and its use in structural elucidationWeek 8:Analysis of spectra of 19F, 31P, 199Hg, 7Li, 15N, 11B, 10B, 29Si, etc.Week 9:2D NMR Concepts, COSYWeek 10:HSQC, HMBC, INADEQUATE, NOESY, J-Resolved, Pulse sequences and Spectral AnalysisWeek 11:Combined Utility of 1D and 2D techniques for Structure elucidation, with examplesWeek 12:Practical Aspects of Data Acquisition and Processing