Immunology

The course will provide basic knowledge of Immunology for UG students in the field of Life Science and Biotechnology. The course introduces students to a wide range of topics in immunology starting from cells of immune system, innate and adaptive immune systems, humoral immunity, antibody structure and function, basic immunological techniques, autoimmunity, hypersensitivity and vaccine production. The course is well balanced with the basics of immunology as well as advanced topics delivered easily for UG students in particular.INTENDED AUDIENCE :Any branch of life sciencesPREREQUISITES :Bichemistry, Microbiology, Cell and molecular biology. INDUSTRIES SUPPORT :Biologics, Biopharma Industry, Vaccine industry

Week 1: Introduction to immune System, Immune cell types, Hematopoiesis, B and T lymphocytes, NK cells, Lymphoid organs (primary and secondary)
Week 2: Features of/introduction to inflammation, Adaptive immune system, Innate Immune system
Week 3: Antibody structure, Generation of antibody diversity
Week 4: Generation of antibody diversity and TCR rearrangement
Week 5: Major histocompatibility complex, Antigen presentation, APCs
Week 6: Immuno-diffusion assay, ELISA (Sandwich), Immuno-blotting, flowcytometry.
Week 7: T-cell development, negative/positive selection,co-stimulatory molecules.
Week 8: Humoral immunity/Cell-mediated immunity, T cell subtypes: Th1, Th2, Th17, Tregs etc.
Week 9: B-cell maturation/activation BCR signaling, memory B and T cell
Week 10:Pro-inflammatory and anti-inflammatory cytokines,cell polarization/Complement activation (classical/alternate), hypersensitivity
Week 11: Autoimmunity, host vs graft reaction
Week 12:Active immunization Vaccines, , Vaccine production, passive immunization. , polyclonal and monoclonal antibodies