Drug Delivery: Principles and Engineering
Offered By: Indian Institute of Science Bangalore via Swayam
Course Description
Overview
This course introduces concepts of drug delivery to meet medical challenges. The course is designed to be modular, with each module focusing on the various aspects of drug delivery.INTENDED AUDIENCE : Anyone in bachelors having completed two yearPREREQUISITES : None. A course in biochemistry, molecular biology, anatomy is recommendedINDUSTRY SUPPORT : All pharmaceuticals, hospitals and biotechnology industries
Syllabus
Week 1: Pharmacokinetics: Bioavailability, Elimination, Therapeutic index
Week 2: Prodrugs, Controlled release
Week 3: Polymers: Synthesis, properties, characterization, crystallinity and amorphousness
Week 4: Biopolymers: Natural and Synthetic, biocompatibility, Biodegradation, commonly used biopolymers
Week 5: Polymer-Drug conjugates, PEGylation
Week 6: Diffusion controlled systems, Ficks laws, Reservoir systems, Non-erodible matrix systems, Bio-erodible Systems
Week 7: Hydrogels: Physical or chemical, pore-size calculation, in-situ crosslinking
Week 8: Nano and Micro-particles: Dendrimers, Liposomes, Micelles
Week 9: Metal and polymeric particles, effect of particle shape, charge and elasticity
Week 10: Protein Adsorption and tissue engineering, Drug delivery in tissue engineering
Week 11: Implant associated infections, Route specific delivery: Oral, Subcutaneous, Intramuscular, transdermal, inhalation, intravenous
Week 12: Vaccines, Cancer vaccines, Cell and gene delivery, Smart responsive drug delivery, Targeted drug delivery, Nanotoxicology and market translation
Taught by
Prof. Rachit Agarwal
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