Medicine Grand Rounds - COVID-19 as Immunology Boot Camp: Cytokine Release Syndrome & Prospects for Therapy

Dartmouth Health Continuing Education for Professionals Home, Medicine Grand Rounds - COVID-19 as Immunology Boot Camp: Cytokine Release Syndrome & Prospects for Therapy, 7/17/2020 8:00:00 AM - 7/17/2023 9:00:00 AM, Dr. Calabrese frames his presentation around three possible scenarios; an asymptomatic innate immunity response, a non-severe adaptive immunity response, and a severe or hyperinflammatory response which can result in multi-system compromise. He discusses how pathogens engage the immune response, resulting in damage recognition that prompts protection, and how mortality can be predicted based on risk factors and chemical markers such as LDH, CRP and lymphocytes. Dr. Calabrese reviews multiple studies and trials currently underway, and the most promising therapies for each stage of this challenging disease.

Presenter
Leonard H. Calabrese, DO
Professor of Medicine
Director, RJ Fasenmyer Centre for Clinical Immunology
Vice Chair, Department of Rheumatic and Immunologic Disease
Co-director, Centre for Vasculitis Care and Research
Cleveland Clinic Lerner College of Medicine
Case Western Reserve University, Cleveland, Ohio

About our Presenter
Leonard Calabrese has particular interest in vascular inflammatory disease of the central nervous system, primary and secondary immunodeficiency states and the intersection of infections and autoimmunity.

Learning Outcome(s)
Participants will be able to describe SARS-CoV2 host-virus interactions resulting in triphasic immunopathogenesis, critically appraise data regarding the integrated immune response in viral defense, disease severity and mortality, and relate mechanisms of action and risk/benefit profiles of targeted therapies as adjuncts to treat COVID-19.

Disclosure
In accordance with the disclosure policy of Dartmouth-Hitchcock/Geisel School of Medicine at Dartmouth as well as standards set forth by the Accreditation Council on Continuing Medical Education and the Nursing Continuing Education Council standards set forth by the American Nurses Credentialing Center Commission on Accreditation, continuing medical education and nursing education activity director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have been asked to disclose any financial relationship* they have to a commercial interest (any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients). Such disclosure is not intended to suggest or condone bias in any presentation, but is elicited to provide participants with information that might be of potential importance to their evaluation of a given activity.

The following Activity Physician Director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have reported the following financial interest or relationship* with various companies/organizations. The Activity Director and Planning Committee member roles were resolved by altering the individual’s control over content about the products or services of the commercial interest by the Associate Dean for CME and the Department of Medicine Chair. The potential speaker conflict has been resolved by validating the activity content through independent peer review by Kelly Kieffer, MD. All potential conflict(s) were resolved.

* Kelly Kieffer, MD ~ her spouse is a consultant for OcculoBio. 

* Richard I. Rothstein, MD ~ has research support from Baranova (research grant to Dartmouth-Hitchcock Medical Center) and is on the Scientific Advisory Board for Allurion.

* Leonard H. Calabrese, DO ~ reports being a consultant for Genentech, Sanofi, Bristol Meyers Squibb, UCB, GlaxoSmithKline, and AbbVie.

Other planning committee member(s), speaker(s), activity director(s), author(s) or anyone in a position to control the content for this program report no financial interest or relationship* with any company(ies) or organizations whose product may be germane to the content of their presentations.

*A “financial interest or relationship" refers to an equity position, receipt of royalties, consultantship, funding by a research grant, receiving honoraria for educational services elsewhere, or to any other relationship to a company that provides sufficient reason for disclosure, in keeping with the spirit of the stated policy.

Bibliographic Material
See presentation for bibliographic sources to allow for further study.