Translating understanding of neural network dysfunction into novel, mood disorder risk markers and brain-based treatments for Bipolar Disorder

Mary L. Phillips M.D. M.D.(Cantab) Pittsburgh Foundation – Emmerling Endowed Chair in Psychotic Disorders Professor in Psychiatry and Clinical Translational Science Director of the Center for Research on Translational and Developmental Affective Neuroscience Director of the Collaborative on Mood Disorders Research Director of the Mood and Brain Laboratory The Clinical and Translational Affective Neuroscience Program Department of Psychiatry, Western Psychiatric Hospital University of Pittsburgh School of Medicine, Pittsburgh, PA, USA This presentation is supported by COBRE Center for Neuromodulation.

• Understand how largescale neural network dysfunction in infancy and childhood confers risk for future mood disorders
• Understand how specific structural and functional abnormalities in the reward network confer risk for future mania and Bipolar Disorder
• Understand how these neural network abnormalities can be targeted by novel neuromodulation interventions aiming to reduce future risk for mood disorders