Why Do We Age? The Molecular Mechanisms of Ageing

Offered By: University of Groningen via FutureLearn

Course Description

Overview

Discover the science behind the ageing process

The “why” and “how” of ageing has puzzled mankind ever since it questioned its place in the universe.

However, it was only after infectious diseases became more controlled and reliable food supplies became generally available, that the rapid increase of the average lifespan made science turn its attention to study longevity and ageing.

To fulfil the desire to live longer and age healthier, it is essential that we better understand the intricate molecular processes that evolve in our body when we age.

Study the concepts and theories of ageing

In this free online course, you will study the current concepts and theories of ageing. You will learn about the molecular and cellular processes in ageing. You will explore the cell systems, animal models and advanced experimental methods that we use to study ageing.

After introducing the main theories and mechanisms of ageing in the first week, we will proceed with a series of in-depth lectures from distinguished researchers working at the European Research Institute for the Biology of Ageing at the University of Groningen. They will present you with a selection of their current research and will explain the fundamental questions they try to answer and the experimental approaches they use for their studies.

You will learn that ageing starts at the cell level and you will study several phenomena which take place in cells, such as genomic instability, telomere shortening and epigenetic changes.

By completing this course you will gain insight into the fundamental biology of ageing in various simple and complex organisms, including humans.

The course is aimed at anyone interested in understanding the biology of ageing. It requires basic knowledge of biology, though most of the terms are explained and you will receive further support via additional reading.

Syllabus

Cellular ageing

Welcome
Why do we study ageing? What is ageing?
Eukaryotic cell structure
Introduction to mechanisms associated with cellular ageing
Glossary on Week 1
Conclusion to Week 1

Chromosomes and ageing

Introduction to Week 2
Using model organisms in ageing research
Mechanism of ageing in yeast - Replicative ageing
Mechanism of ageing in yeast - Telomeres
Aneuploidy, cancer, and ageing
Glossary on Week 1-2
Conclusion to Week 2

Genomic instability and epigenetics

Introduction to Week 3
DNA damage and repair
Telomeres, stem cells, and ageing
Epigenetics and ageing
Mid-course test
Glossary on Week 1-3
Conclusion to Week 3

Stem cells in ageing and rejuvenation

Introduction to Week 4
Single cell sequencing
Haematopoietic stem cells
Regeneration and rejuvenation
Glossary on Week 1-4
Conclusion to Week 4

Health and disease during ageing - molecular aspects

Introduction to Week 5
Decline and disease
Protein aggregation, toxicity, and neurodegeneration
Calorie restriction - health and lifespan
Glossary on Week 1-5
Conclusion to Week 5

Genetics and evolution of ageing

Introduction to Week 6
Genetics of ageing
Evolutionary theories of ageing
Peer review assignment
Glossary on Week 1-6
Conclusion to Week 6 and general conclusion

Taught by

Marianna Bevova